Republican Ohio gubernatorial candidate Vivek speaks during a watch party at the Spruce St. Sporting sports bar after winning the party's nomination for governor Tuesday, in Columbus. (AP Photo/Carolyn Kaster)

COLUMBUS — Tuesday’s primary in Ohio set up what is expected to be one of the most expensive races for U.S. Senate this year as Republicans try to hold on to the chamber during a difficult midterm year. Meanwhile biotech billionaire Vivek Ramaswamy will face a challenge from the state’s former health director as he seeks to keep the governor’s office in GOP hands.

In what promises to be one of November’s marquee matchups, former Sen. Sherrod Brown easily defeated a challenger in the Democratic primary and will now attempt to unseat Republican Sen. Jon Husted.

Democrats are counting on Brown’s previous popularity with voters to flip the seat. The Senate Leadership Fund, a top GOP super PAC, has pledged $79 million to defend Husted, who was unopposed in his primary.

“Ohioans are fed up with the corruption and greed in Washington,” Brown, who served three terms in the Senate before losing a reelection bid in 2024, said in a social media post after his primary victory. “They deserve a senator who fights for working families, not CEOs and billionaires.”

Husted was unopposed in his primary, a special election to fill the remainder of the six-year Senate term that Vice President JD Vance won in 2022.

In the governor’s race, Ramaswamy clinched the Republican nomination over a minor challenger and will face off this fall against the state’s COVID-era health director, Democrat Amy Acton.

A newcomer to state politics, he aggressively positioned himself for the job early with the help of endorsements from President Donald Trump and the state Republican Party.

“We’re going to revive that American Dream in Ohio once again, with lower costs, bigger paychecks and better schools for all Ohioans,” Ramaswamy said in a statement Tuesday evening.

Both candidates for governor are widely known across Ohio

Trump’s endorsement continues to carry weight in Ohio, which favored him three times for president, but Ramaswamy could face headwinds amid the president’s lagging popularity over the war in Iran and the rising cost of living.

Acton, a physician who was unopposed in her primary, has a well-known public profile and robust fundraising. That has Democrats hopeful she can get the party back in the governor’s office for the first time in 20 years.

Ramaswamy, a 2024 GOP primary presidential candidate, swept onto the state’s political scene early last year as a mad shuffle was taking place. Then-Sen. Vance was ascending to the vice presidency, and front-running gubernatorial candidate Jon Husted was being appointed to replace him in Washington.

That opened a window of opportunity at the top of Republicans’ statewide ticket.

Every statewide executive office was open this year due to term limits, but the governor’s race captured the bulk of the attention.

National economy, COVID-19 pandemic set early tone for governor’s race

Ramaswamy’s national profile, tech industry connections and proximity to Trump landed him the Ohio Republican Party’s endorsement. With it he cleared a prospective field that included the sitting state attorney general, state treasurer and lieutenant governor.

But Democrats also see opportunity with the open governors seat, even as the state, a former bellwether, has tipped convincingly toward Republicans during the Trump era.

Acton, a physician and public health expert, emerged as their choice. She became a household name across Ohio in the early days of the COVID-19 pandemic as she stood alongside Republican Gov. Mike DeWine during daily coronavirus broadcasts. Her comforting presence during the crisis made her a beloved figure with many Ohioans.

“I just think she’s real,” said Aaron Weiner, a Cincinnati real estate agent who voted for Acton. “She has had struggles, so I think she can empathize with people who are struggling to get ahead.”

But the administration’s aggressive actions — including shuttering businesses, closing schools and canceling an election — also earned Acton plenty of enemies and made her the occasional target of people upset about pandemic policies, with some armed protesters showing up outside her home.

Ramaswamy’s campaign sought to capitalize on the lingering anger over pandemic restrictions with attacks on Acton’s role early in the crisis. Ramaswamy was advising the lieutenant governor at the time — Husted — on virus-related economic issues and he founded a company that profited off its role developing vaccines.

Ramaswamy faced a long-shot challenge in his primary from Casey Putsch. The engineer and car designer is a YouTube provocateur who trolled Ramaswamy incessantly over his Indian heritage and Hindu faith and painted him as an out-of-touch billionaire “tech bro.”

Cincinnati voter Paul Mussman, who cast his ballot for Ramaswamy, said he considers it an asset that he is a relative newcomer to politics.

Ramaswamy would look at issues “in a fresh way and not based on what their party affiliation is,” Mussman said.

Republicans see some Democratic-held House seats as vulnerable

In the wake of a new round of redistricting that slightly favored Republicans, the state also had numerous partisan congressional primaries.

The most heated GOP primary was in the Toledo area’s 9th District for the chance to take on Democratic U.S. Rep. Marcy Kaptur, the longest-serving woman in Congress.

The five-way contest included former state Rep. Derek Merrin, whom Kaptur defeated by less than a percentage point in 2024, as well as an Air National Guard veteran, a healthcare industry worker, a sitting state representative and the former deputy director of U.S. Immigration and Customs Enforcement, Madison Sheahan.

In Democratic U.S. Rep. Greg Landsman’s Cincinnati-area district, which his party considers a “must-hold,” the three-way Republican primary included Eric Conroy, a CIA and Air Force veteran who was endorsed by Trump, Vance and Moreno.

Landsman beat back a primary challenge of his own Tuesday from Damon Lynch IV, the grandson of a prominent civil rights leader. Lynch had criticized Landsman for his initial vote against a war powers resolution on the war in Iran, which Landsman later followed up with a favorable vote.

In the Akron area’s 13th District, five Republicans including business owner Neil Patel, a 2022 U.S. Senate candidate, were vying for the opportunity to face Democratic U.S. Rep. Emilia Sykes.

Democrats think new House maps give them a shot to regain seats

As a Trump-backed national effort to remake congressional maps in Republicans’ favor was underway, Ohio Democrats took a could-have-been-worse approach and passed the map they were given unanimously.

Now party candidates are crowding congressional primaries across the state for the chance to take on sitting Republican representatives, who hold 10 of Ohio’s 15 seats.

The newly redrawn 7th District in the Cleveland area attracted eight Democrats hoping to challenge Republican U.S. Rep. Max Miller, a former senior Trump adviser, in November. Among them was former Cuyahoga County Executive Ed FitzGerald, the Democratic nominee for governor in 2014.

In northeast Ohio’s 14th District, former state Supreme Court Justice William O’Neill was among three Democrats seeking to take on Republican U.S. Rep. Dave Joyce. Joyce also has two primary challengers.

Meanwhile six Democrats were on the ballot in the Dayton-area 10th District of Republican U.S. Rep. Mike Turner. There were seven in GOP U.S. Rep. Michael Rulli’s 6th District along the Ohio River and five in the 5th District of Republican U.S. Rep. Bob Latta.